Lipophilic β-Cyclodextrin Cyclic−Nitrone Conjugate: Synthesis and Spin Trapping Studies
نویسندگان
چکیده
منابع مشابه
Spin trapping of hydroperoxyl radical by a cyclic nitrone conjugated to β-cyclodextrin: a computational study.
Spin trapping of hydroperoxyl radical (HOO.) by the amide-linked conjugate of 5-carbamoyl-5-methyl-1-pyrroline N-oxide (AMPO) to β-cyclodextrin (β-CD) was studied computationally using a two-layered ONIOM method. From a conformational perspective, the "internal" conformation of 5R-β-CD-AMPO is more favored than the "external" conformation in which the nitrone is located outside of the cavity of...
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Amphiphilic cyclodextrin–fullerene conjugates have potential biological activity, due to their water solubility. In order to study the influence of the linker of these conjugates on solubility and aggregation, a permethylated β-cyclodextrin–C60 conjugate with a short linker –(CH2)2NHCO–, which is attached to the secondary face of β-cyclodextrin was synthesized. Its solubility in water and its U...
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Nateglinide(NTG), Repaglinide(RPG), and Glimepiride(GMP) are antidiabetic drugs. These antidiabetic drugs are poorly soluble in water, which affect the bioavailability. In the present work, complex formation of all the three drugs with b-cyclodextrin (b-CD) and Hydroxy propyl bcyclodextrin (HPb-CD) and then the possibility of improving the solubility of NTG, RPG and GMP by complexation with b-C...
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This study presents the influence of hydroxypropyl-β-cyclodextrin (HPBCD) on the aqueous solubility of acyl esters of cyproterone. First, a number of esters of cyproterone were synthesized. Then the phase solubility analysis of the compounds in the presence of HPBCD was investigated in phosphate buffer solution at a pH of 7.4. To gain a better understanding of the complexation mechanism, ...
متن کاملSpin trapping studies of photochemical reactions
Spin trapping is a very useful technique to study the photochemistry of chemical photosensitizers that undergo electron or hydrogen-transfer (Type I) reactions upon UV or visible irradiation. The Type I photochemistry of chlorpromazine [2-chloro-N-(3-dimethylaminopropy1)-phenothiazine], 3,3'4'5-tetrachlorosalicylanilide and 3,4',5tribromosalicylanilide has been investigated using 2-methyl-2-nit...
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ژورنال
عنوان ژورنال: The Journal of Organic Chemistry
سال: 2009
ISSN: 0022-3263,1520-6904
DOI: 10.1021/jo900856x